Effect of a gynaecological thermal treatment on the hypothalamic-pituitary ovarian axis in premenopausal women

Autori: V. Coiro, L.Irali, G.Saccani Jotti, G.Varacca
Titolo: Effect of a gynaecological thermal treatment on the hypothalamic-pituitary ovarian axis in premenopausal women
Descrizione: Objective:Premenopause is charactarized by colpocytologic deterioration, anovulatory menstrual cycles,progressive reduction in serum ovarian steroids and increased gonadotropin levels. Improvements in colpocytologic parameters and in menstrual cycle regularity have been observed in premenopausal women after thermal treatment with salsobromoiodic water. The aim of this study has been to establish whether these clinical observations could be associated with sex hormone change. Methods: Colpocytologic test and serum FSH, LHG,17-betaestradiol (E2) and progesterone (P) levels have been evaluated at the 22nd day of 2 following mestrual cycles in 65 healthy premenopausal women. During the month between tests, the were subdivided into two groups: A) 45 subjects (experimental group) underwent a gynaecological thermal treatment with salsobromoiodic water, whicht stardet after menstruation (15 morning immersion up to the neck in water at 37°C and 15 vaginal irrigations at 38°C with increasing water density); B) 20 subject (control group) receveid a standard pharyngeal inhalant teatment. Furthermore, in order to evaluate the effects of the treatment on clinical symptoms sensitive to estrogen deficiency, such as hot flush, palpitation, insomnia and genitourinary disturbances, all subjects answared a questionnaire at the time of recruitment and 6 months later. Result: All women showed low serum E2 an P levels and elevated gonadotropin concentrations before thermal treatments. While hormonal values did not change after pharingeal inhalations in the control group, the subjects on the experimental group showed a significant increase in both serum E2 and P concentartions, with a significant decrease in serum FSH levels. Two endocrine markers of ovulation, LH maggFSH and P magg5ng/mL, were simultanneously present in just 7 outof the 45 subjects of the experimental group in the first test, whereas they were present in 18 subjects after gynaecological thermal treatment a significant improvedment alterations and clinical symptoms was observed in the experimental group, where as no change wasd found in the control group. Conclusion: these data show a significant improvedement of the hypothalamic-pituitary ovarian dysfunctions in premenopausal women after gynaecological thermal treatment. The improved ovarian steroid milieu might be at least in part responsible for the clinically evident amelioration observed after thermal therapy.
Istituto promotore: Department of Internal Medicine and Biomedical Sciences,University of Parma, Terme di Salsomaggiore, Department of Public Health University of Parma
Sezione: ginecologia
Rivista: It.J.Gynaecol.Obstet. 14:N°4:115-120,2002