Combination treatment whith etanercept and an intensive spa rehabilitation program in active ankilosing spondylitis

Autori: M. Colina, G. Ciancio, R. Garavini, M. Conti, F. Trotta and M. Govoni
Titolo: Combination treatment whith etanercept and an intensive spa rehabilitation program in active ankilosing spondylitis
Descrizione: The aim of this study is to determine the effects of a combination treatment with etanercept and spa rehabilitation versus etanercept alone on function, disability and quality of life in a group of patients with active ankylosing spondylitis (AS). Sixty patients AS underwent etanercept as suggested by ASAS/EULAR recommendations. As the clinical and laboratory conditions improved, 30 patients accepted the proposal of coupling the medical therapy with a 7-day rehabilitation program in a thermal baths centre; the remaining 30 subjects continued to take the biologic agent alone. The comparisons between the 2 groups were made after 3 and 6 months. The primary outcome was an improvement in BASFI. The secondary outcome was an improvement in the visual analogic scale of EuroQol (EQ-5Dvas). After 6 months a statiscally significant improvement in BASFI (p min 0.05) and EQ-5Dvas (p< 0.05) scores was observed in both groups. The mean change in EQ-5Dvas value showed a statiscally significant difference in favour of the combination therapy group versus the monotherapy group (22 vs32, p < 0.05). A therapeutic regimen combining etanercept whit an intensive rehabilitation program contributes to disability reduction and ameliorates quality of life for AS patients
Istituto promotore: Reumathology section department of Clinical and esperimental Medice University of Ferrara, Presidio di Medicina Fisica e Riabilitazione delle Terme di Castrocaro
Sezione: riabilitazione
Rivista: International Journal of Immunopathology and pharmacology. vol 22-n 4:1125-1129,2009