Autori: V.Coiro, P.P. Vescovi
Titolo: Improvement of haemorrheological alterations in alcoholicistics by sulfureus water treatment
Descrizione: Blood and plasma viscosy, and whole blood filterability (VB), were evaluated in 10 normale controls ( 40-60 years old) and 20 age- matched alcoholic patiens before and after treatment for 2 weeks with 500 ml/day p.o. of sulfurous water (n. 10) or a placebo (aqua fontis) (n.10). metabolic ( total cholesterol, triglyceride, uric acid, fasting glucose and fibrinogen levels) and haematological (red, white cell and platelet count; haematocrit; mean red cell volume) paramenters and plasma glutathione (GSH) levels were also measured in all experimental conditions. Plasma viscosity, fibrinogen and all examined metabolic and haematological (except platelets) paraments were similar in normal controls and alcoholic patients regardless of the use of sulfurous water or placebo. Platelets were always lower in alcoholics than in normal controls. In contrast, alcoholic men showed significantly higher levels of blood viscosity and lower values of VB and plasma GSH levels than normale controls. Two weeks of treatment with the placebo did not change haemorrheological alterations and plasma significatly increased VB values and plasma GSH levels. These data suggest the existence of alterations in red cell plasticity in alcoholics, which can reversed by treatment with sulfurous water, probably by reconstituction of normal cell membrane structure and function.
Istituto promotore: Università di Parma
Rivista: Alcologia,7(1),27-33,1995
Sezione: farmacologia
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