Effetti indotti dalle acque termali sulfuree-salso-bromo-iodiche sulle concentrazioni di Albumine e IgA secretorie del secreto nasale

Autori: A.Staffieri, C.Miani, A.M. Bergamin, P.Arcangeli,P.Canzi
Titolo: Effetti indotti dalle acque termali sulfuree-salso-bromo-iodiche sulle concentrazioni di Albumine e IgA secretorie del secreto nasale
Descrizione: In chronic rhinopharyngotubaric phlogoses, the key pathogenic element sustaining phlogosis is a persistent modification of the biological, rheological feautures of the nasal mucus. For centuries sulphurous thermal waters have proved effective in clinically curing such phlogoses. In order to evaluate the effect of such sulphurous-salsy-bromic-iodic thermal water a randomized, double blid study was undertaken on a sampling of 50 patients. The effect such water have on secretory IgA (sIgA) and albumin in nasal secretions was tested against a placebo made of distilled water. Using the method of radial immunodiffusion, the response in the IgAs (mg-l)and albumin (mg-dl) concentrations in the nasal secretions was measured for 25 patients treated with distilled water. The average concentrations were statistically compared using the Student t-test for paired samples. A significant increase (p magg 0.0001) was seen in the mean IgAs concentrations in the patients treated with the thermal waters. On the other hand,there was a weak,not statistically ignificant increase in the same data mean for the group treated with distilled water. The average increase in the albumin concentration in the nala secretions proved significant in both casee although the significance was much more marked in the group treated with the thermal waters (p uguale 0.0001) vs. the placebo group (p.uguale 0.039).
Istituto promotore: Clinica ORL Uni Padova, Clinica ORL Uni Udine, Terme di Riccione, Div. ORL Ospedale di Rimini
Rivista: Acta Otorhinolaryngol Ital,18,233-238,1998
Sezione: ORL