Autori: Mirandola P ,a, Gobbi G ,a, Sponzilli I ,a, Pambianco M ,b, Malinverno C ,a, Cacchioli A ,c, De Panfilis G ,d , Vitale M ,a.
Titolo: Exogenous Hydrogen Sulfide Induces Functional Inhibition and Cell Death of Cytotoxic Lymphocytes Subsets
Descrizione: The toxic effects of exogenous hydrogen sulfide on peripheral blood lymphocytes have been investigated in detail. Hydrogen sulfide is now considered as a gasotransmitter with specific functional roles in different cell types, like neurons and vascular smooth muscle. Here we show that exogenous hydrogen sulfide induces a caspase-independent cell death of peripheral blood lymphocytes that depends on their intracellular glutathion levels, with a physiologically relevant subset specificity for CD8+ cells and NK cells. Although lymphocyte activation does not modify their sensitivity to HS-, after 24 h exposure to hydrogen sulfide surviving lymphocyte subsets show a dramatically decreased proliferation in response to mitogens and a reduced IL-2 production. Overall, our data demonstrate that HS- reduces the cellular cytotoxic response of peripheral blood lymphocytes as well as their production of IL-2, therefore deactivating the major players of local inflammatory responses,adding new basic knowledge to the clinically well known antiinflammatory effects of sulfur compounds.
Istituto promotore: a – Department of Anatomy, Pharmacology & Forensic Medicine,Human Anatomy Section, University of Parma, Ospedale Maggiore,via Gramsci, Parma, Italy. b – Terme di Sirmione, Cell Biology Laboratory, Terme di Sirmione, Brescia, Italy. c – Department of Animal Health, University of Parma, Italy. d – Department of Surgery, Section of Dermatology, University of Parma, Italy
Rivista: J. Cell. Physiol. 213: 826–833, 2007. 2007 Wiley-Liss, Inc. ORIGINAL ARTICLE 826 Journal of Cellular Physiology
Sezione: farmacologia – ricerca tratta da sito Fondazione Forst
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